Scientific Research

Creatine Monohydrate in Muscular Dystrophies: A Double-Blind, Placebo-Controlled Clinical Study 

M.C. Walter, MD; H. Lochmuller, MD; P. Reilich, MD; 
T. Klopstock, MD; R. Huber, MD; M. Hartard, MD; 
M. Hennig, MSc; D. Pongratz, MD; and W. Muller-Felber, MD

Abstract

The authors assessed the safety and efficacy of creatine monohydrate (Cr) in various types of muscular dystrophies in a double-blind crossover trial. Thirty-six patients (12 patients with facioscapulohumeral dystrophy, 10 patients with Becker dystrophy, 8 patients with Duchenne dystrophy, and 6 patients with sarcoglycan-deficient limb girdle muscular dystrophy) were randomized to receive Cr or placebo for 8 weeks. There was mild but significant improvement in muscle strength and daily-life activities by Medical Research Control scales and the Neuromuscular Symptom Score. Cr was well tolerated throughout the study period.

COPYRIGHT NOTICE:  Copyrighted material on this website may not be reproduced, archived or redistributed in any form without written consent.